Bioactive Small Molecules
A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.
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961
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975
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961
Tocris Bioscience™ Liproxstatin-1 hydrochloride
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Additional Apoptosis-related Compounds
| Target | Ferroptosis Inhibitors |
|---|---|
| Purity | 98% |
| Recommended Storage | Store at -20°C |
| Synonym | N-[(3-Chlorophenyl)methyl]spiro[piperidine-4,2′(1′H)-quinoxalin]-3′-amine hydrochloride |
| Molecular Formula | C19H21ClN4.HCl |
| Formula Weight | 377.31 |
962
Tocris Bioscience™ Lenalidomide 4'-PEG2-amine
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Cereblon ligand with PEG linker and terminal amine for onward chemistry
963
Tocris Bioscience™ Janelia Fluor 549, SE
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Yellow dye (Reactive group: NHS ester). Applications: super resolution microscopy e.g. dSTORM & STED, confocal, flow and live cell imaging
964
Tocris Bioscience™ Ivacaftor
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Potent and selective CFTR potentiator
| Target | CFTR |
|---|---|
| CAS | 873054-44-5 |
| Purity | 98% |
| Chemical Name or Material | N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxo-3-quinolinecarboxamide |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C24H28N2O3 |
965
Tocris Bioscience™ TTNPB
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CAS: 71441-28-6 Molecular Formula: C24H28O2
| CAS | 71441-28-6 |
|---|---|
| Molecular Formula | C24H28O2 |
966
Tocris Bioscience™ (S)-SNAP 5114
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CAS: 157604-55-2 Molecular Formula: C30H35NO6
| CAS | 157604-55-2 |
|---|---|
| Molecular Formula | C30H35NO6 |
967
Tocris Bioscience™ AbK
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Photo-crosslinking probe; unnatural amino acid
968
Tocris Bioscience™ SJF 1528
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Potent EGFR PROTAC™; also degrades HER2
969
Tocris Bioscience™ ARCC 4 negative control
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Negative control for ARCC 4 (Cat. No. 7254)
970
Tocris Bioscience™ AUTAC4
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Mitochondrial targeting AUTAC Degrader
971
Tocris Bioscience™ DCEBIO
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Activates Cl- conductance and hKCa3.1 channels
| CAS | 60563-36-2 |
|---|---|
| Solubility | Soluble to 100mM in DMSO |
| Chemical Name or Material | 5,6-Dichloro-1-ethyl-1,3-dihydro-2H-benzimidazol-2-one |
| Recommended Storage | Store at Room Temperature |
| Molecular Formula | C9H8Cl2N2O |
| Formula Weight | Observed MW: 231.08 |
| Assay Percent Range | >99% |
972
Tocris Bioscience™ VAS 2870
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NADPH oxidase (Nox) inhibitor
| CAS | 722456-31-7 |
|---|---|
| Purity | 98% |
| Chemical Name or Material | 7-(2-Benzoxazolylthio)-3-(phenylmethyl)-3H-1,2,3-triazolo[4,5-d]pyrimidine |
| Recommended Storage | Store at 4°C |
| Molecular Formula | C18H12N6OS |
| Formula Weight | 360.39 |
973
Tocris Bioscience™ DS2
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Positive allosteric modulator of δ-containing GABAA receptors
| Inhibitors | DS2 |
|---|---|
| Product Type | DS2 |
| Molecular Weight (g/mol) | 353.83 |
| Purity | >97% |
974
Tocris Bioscience™ LEI 101 hydrochloride
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CAS: 2250025-91-1
| CAS | 2250025-91-1 |
|---|
975
Tocris Bioscience™ Baricitinib
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Highly potent JAK1 and JAK2 inhibitor; also inhibits JAK3 and Tyk2